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KMID : 0380620210530050509
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Korean Journal of Food Science and Technology
2021 Volume.53 No. 5 p.509 ~ p.513
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Effects of curcumin on human health ? A reassessment
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Kim Dae-Ok
Lee Chang-Yong
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Abstract
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Curcumin is known to possess diverse beneficial physiological effects including antioxidant, anti-inflammatory, anti-depressant, anti-microbial, and anti-neoplastic activities, as well as immune-modulating, metabolism-regulating, and neuroprotective effects. However, despite more than 13,000 research papers published during the last ten years regarding the health benefits of curcumin, curcumin has not been introduced in the market as a pharmaceutical agent in any country.
Despite the abundance of positive findings, most investigations that tout its health benefits are based on in vitro and in vivo studies that fail to consider the protean chemical behaviors of curcumin, which is known to be a pan-assay interference compound and an invalid metabolic panacea. Therefore, human clinical trials, despite rigorous study design, have been unable to prove specific benefits. This article reviews the pleiotropic properties of curcumin so that they can be balanced against its beneficial effects and suggests potential research avenues to better understand its health benefits.
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KEYWORD
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bioavailability, hormesis, pan-assay interference compound, polyphenol, turmeric
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